Event
|
Date
|
Location
|
Disease
|
Death toll (estimate)
|
Ref.
|
1200 BC Babylon influenza epidemic
|
1200 BC
|
Babylon, or Babirus of the Persians, Central Asia, Mesopotamia and Southern Asia
|
Sanskrit scholars found records of a disease resembling the Flu
|
Unknown
|
[11]
|
Plague of Athens
|
429–426 BC
|
Greece, Libya, Egypt, Ethiopia
|
Unknown, possibly typhus, typhoid fever or viral hemorrhagic fever
|
75,000–100,000
|
[12][13][14][15]
|
412 BC epidemic
|
412 BC
|
Greece (Northern Greece, Roman Republic)
|
Unknown, possibly influenza
|
Unknown
|
[16]
|
Antonine Plague
|
165–180 (possibly up to 190)
|
Roman Empire
|
Unknown, possibly smallpox
|
5–10 million
|
[17][18]
|
Jian'an Plague
|
217
|
Han Dynasty
|
Unknown, possibly typhoid fever or viral hemorrhagic fever
|
Unknown
|
[19][20]
|
Plague of Cyprian
|
250–266
|
Europe
|
Unknown, possibly smallpox
|
Unknown
|
[21][22]
|
Plague of Justinian (beginning of First plague pandemic)
|
541–549
|
Europe and West Asia
|
Bubonic plague
|
15–100 million (25–60% of population of Europe)
|
[5][23][24]
|
Roman Plague of 590 (part of First plague pandemic)
|
590
|
Rome, Byzantine Empire
|
Bubonic plague
|
Unknown
|
[25]
|
Plague of Sheroe (part of First plague pandemic)
|
627–628
|
Bilad al-Sham
|
Bubonic plague
|
25,000+
|
|
Plague of Amwas (part of First plague pandemic)
|
638–639
|
Byzantine Empire, West Asia, Africa
|
Bubonic plague
|
25,000+
|
[26]
|
Plague of 664 (part of First plague pandemic)
|
664–689
|
British Isles
|
Bubonic plague
|
Unknown
|
[27]
|
Plague of 698–701 (part of First plague pandemic)
|
698–701
|
Byzantine Empire, West Asia, Syria, Mesopotamia
|
Bubonic plague
|
Unknown
|
[28]
|
735–737 Japanese smallpox epidemic
|
735–737
|
Japan
|
Smallpox
|
2 million (approx. 1⁄3 of Japanese population)
|
[10][29]
|
Plague of 746–747 (part of First plague pandemic)
|
746–747
|
Byzantine Empire, West Asia, Africa
|
Bubonic plague
|
Unknown
|
[26]
|
Black Death (start of the Second plague pandemic)
|
1346–1353
|
Europe, Asia and North Africa
|
Bubonic plague
|
75–200 million (30–60% of European population)
|
[30]
|
Sweating sickness (multiple outbreaks)
|
1485–1551
|
Britain (England) and later continental Europe
|
Unknown, possibly an unknown species of hantavirus
|
10,000+
|
[31]
|
1489 Spain typhus epidemic
|
1489
|
Spain
|
Typhus
|
17,000
|
[32]
|
1510 influenza pandemic
|
1510
|
Asia, North Africa, Europe
|
Influenza
|
Unknown, around 1% of those infected
|
[33]
|
1520 Mexico smallpox epidemic
|
1519–1520
|
Mexico
|
Smallpox
|
5–8 million (40% of population)
|
[6]
|
Cocoliztli Epidemic of 1545–1548
|
1545–1548
|
Mexico
|
Possibly Salmonella enterica
|
5–15 million (80% of population)
|
[34][35][36][37]
|
1557 influenza pandemic
|
1557–1559
|
Asia, Africa, Europe, and Americas
|
Influenza
|
Unknown
|
|
1561 Chile smallpox epidemic
|
1561–1562
|
Chile
|
Smallpox
|
Unknown (20–25% of native population)
|
[38]
|
1563 London plague (part of the Second plague pandemic)
|
1563–1564
|
London, England
|
Bubonic plague
|
20,100+
|
[39]
|
Cocoliztli epidemic of 1576
|
1576–1580
|
Mexico
|
Possibly Salmonella enterica
|
2–2.5 million (50% of population)
|
[34][35][36][37]
|
1582 Tenerife plague epidemic (part of the Second plague pandemic)
|
1582–1583
|
Tenerife, Spain
|
Bubonic plague
|
5,000–9,000
|
[40]
|
1592–1596 Seneca nation measles epidemic
|
1592–1596
|
Seneca nation, North America
|
Measles
|
Unknown
|
[41]
|
1592–93 Malta plague epidemic (part of the Second plague pandemic)
|
1592–1593
|
Malta
|
Bubonic plague
|
3,000
|
[42]
|
1592–93 London plague (part of the Second plague pandemic)
|
1592–1593
|
London, England
|
Bubonic plague
|
19,900+
|
[43]
|
1596–1602 Spain plague epidemic (part of the Second plague pandemic)
|
1596–1602
|
Spain
|
Bubonic plague
|
600,000–700,000
|
[44]
|
1600–1650 South America malaria epidemic
|
1600–1650
|
South America
|
Malaria
|
Unknown
|
[citation needed]
|
1603 London plague epidemic (part of the Second plague pandemic)
|
1603
|
London, England
|
Bubonic plague
|
40,000
|
[45][46][47]
|
1616 New England infections epidemic
|
1616–1620
|
Southern New England, British North America, especially the Wampanoag people
|
Unknown, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D
|
Unknown (estimated 30–90% of population)
|
[48][49]
|
1629–1631 Italian plague (part of the Second plague pandemic)
|
1629–1631
|
Italy
|
Bubonic plague
|
1 million
|
[50]
|
1632–1635 Augsburg plague epidemic (part of the Second plague pandemic)
|
1632–1635
|
Augsburg, Germany
|
Bubonic plague
|
13,712
|
[51]
|
Massachusetts smallpox epidemic
|
1633–1634
|
Massachusetts Bay Colony, Thirteen Colonies
|
Smallpox
|
1,000
|
[52]
|
1634–1640 Wyandot people epidemic of infections
|
1634–1640
|
Wyandot people, North America
|
Smallpox and Influenza
|
15,000–25,000
|
[53]
|
1637 London plague epidemic (part of the Second plague pandemic)
|
1636–1637
|
London and Westminster, England
|
Bubonic plague
|
10,400
|
[54]
|
Great Plague in late Ming Dynasty (part of the Second plague pandemic)
|
1633–1644
|
China
|
Bubonic plague
|
200,000+
|
[55][56]
|
Great Plague of Seville (part of the Second plague pandemic)
|
1647–1652
|
Spain
|
Bubonic plague
|
500,000
|
[57]
|
1648 Central America yellow fever epidemic
|
1648
|
Central America
|
Yellow fever
|
Unknown
|
[58]
|
Naples Plague (part of the Second plague pandemic)
|
1656–1658
|
Italy
|
Bubonic plague
|
1,250,000
|
[59]
|
1663–1664 Amsterdam plague epidemic (part of the Second plague pandemic)
|
1663–1664
|
Amsterdam, Netherlands
|
Bubonic plague
|
24,148
|
[60]
|
Great Plague of London (part of the Second plague pandemic)
|
1665–1666
|
England
|
Bubonic plague
|
100,000
|
[61][62]
|
1668 France plague (part of the Second plague pandemic)
|
1668
|
France
|
Bubonic plague
|
40,000
|
[63]
|
1675–76 Malta plague epidemic (part of the Second plague pandemic)
|
1675–1676
|
Malta
|
Bubonic plague
|
11,300
|
[64]
|
1676–1685 Spain plague (part of the Second plague pandemic)
|
1676–1685
|
Spain
|
Bubonic plague
|
Unknown
|
[65]
|
1677–1678 Boston smallpox epidemic
|
1677–1678
|
Massachusetts Bay Colony, British North America
|
Smallpox
|
750–1000
|
[66]
|
Great Plague of Vienna (part of the Second plague pandemic)
|
1679
|
Vienna, Austria
|
Bubonic plague
|
76,000
|
[67]
|
1681 Prague plague epidemic (part of the Second plague pandemic)
|
1681
|
Prague, Czech Kingdom
|
Bubonic plague
|
83,000
|
[68]
|
1687 South Africa Influenza outbreak
|
1687
|
South Africa
|
Unknown, possibly Influenza
|
Unknown
|
[69]
|
1693 Boston yellow fever epidemic
|
1693
|
Boston, Massachusetts Bay Colony, British North America
|
Yellow fever
|
3,100+
|
[70]
|
1699 Charleston and Philadelphia yellow fever epidemic
|
1699
|
Charleston and Philadelphia, British North America
|
Yellow fever
|
520 (300 in Charleston, 220 in Philadelphia)
|
[71]
|
1702 New York City yellow fever epidemic
|
1702
|
New York City, British North America
|
Yellow fever
|
500
|
[72]
|
1702–1703 St. Lawrence Valley smallpox epidemic
|
1702–1703
|
New France, Canada
|
Smallpox
|
1,300
|
[73]
|
1707–1709 Iceland smallpox epidemic
|
1707–1709
|
Iceland
|
Smallpox
|
18,000+ (36% of population)
|
[74]
|
Great Northern War plague outbreak (part of the Second plague pandemic)
|
1710–1712
|
Denmark, Sweden, Lithuania
|
Bubonic plague
|
164,000
|
[75][76]
|
1713–1715 North America measles epidemic
|
1713–1715
|
Thirteen Colonies and New France, Canada
|
Measles
|
Unknown
|
[77][78]
|
Great Plague of Marseille (part of the Second plague pandemic)
|
1720–1722
|
France
|
Bubonic plague
|
100,000+
|
[79]
|
1721 Boston smallpox outbreak
|
1721–1722
|
Massachusetts Bay Colony
|
Smallpox
|
844
|
[80]
|
1730 Cádiz yellow fever epidemic
|
1730
|
Cádiz, Spain
|
Yellow fever
|
2,200
|
[81]
|
1732–1733 Thirteen Colonies influenza epidemic
|
1732–1733
|
Thirteen Colonies
|
Influenza
|
Unknown
|
[82]
|
1733 New France smallpox epidemic
|
1733
|
New France, Canada
|
Smallpox
|
Unknown
|
[83]
|
1735–1741 Diphtheria epidemic
|
1735–1741
|
New England, Province of New York, Province of New Jersey, British North America
|
Diphtheria
|
20,000
|
[84]
|
Great Plague of 1738 (part of the Second plague pandemic)
|
1738
|
Balkans
|
Bubonic plague
|
50,000
|
[85]
|
1738–1739 North Carolina smallpox epidemic
|
1738–1739
|
Province of Carolina, Thirteen Colonies
|
Smallpox
|
7,700–11,700
|
[86]
|
1741 Cartagena yellow fever epidemic
|
1741
|
Cartagena, Colombia
|
Yellow fever
|
20,000
|
[87]
|
1743 Sicily plague epidemic (part of the Second plague pandemic)
|
1743
|
Messina, Sicily, Italy
|
Bubonic plague
|
40,000–50,000
|
[88][89]
|
1759 North America measles outbreak
|
1759
|
North America
|
Measles
|
Unknown
|
[90]
|
1760 Charleston smallpox epidemic
|
1760
|
Charleston, British North America
|
Smallpox
|
730–940
|
[91][92]
|
1762 Havana yellow fever epidemic
|
1762
|
Havana, Cuba
|
Yellow fever
|
8,000
|
[87]
|
1763 Pittsburgh area smallpox outbreak
|
1763
|
North America, present-day Pittsburgh area
|
Smallpox
|
Unknown
|
[93]
|
Russian plague of 1770–1772 (part of the Second plague pandemic)
|
1770–1772
|
Russia
|
Bubonic plague
|
50,000
|
[94]
|
1772 North America measles epidemic
|
1772
|
North America
|
Measles
|
1,080
|
[95]
|
1772–1773 Persian Plague (part of the Second plague pandemic)
|
1772–1773
|
Persia
|
Bubonic plague
|
2 million
|
[96]
|
1775–1776 England influenza outbreak
|
1775–1776
|
England
|
Influenza
|
Unknown
|
[97]
|
1775–1782 North American smallpox epidemic
|
1775–1782
|
Native populations in what is now the Pacific Northwest of the United States
|
Smallpox
|
11,000+
|
[98][99]
|
1778 Spain dengue fever outbreak
|
1778
|
Spain
|
Dengue fever
|
Unknown
|
[100]
|
1788 Pueblo Indians smallpox epidemic
|
1788
|
Pueblo Indians in northern New Spain (what is now the Southwestern United States)
|
Smallpox
|
Unknown
|
[101]
|
1789–1790 New South Wales smallpox epidemic
|
1789–1790
|
New South Wales, Australia
|
Smallpox
|
Unknown (50–70% of native population)
|
[102][103]
|
1793 Philadelphia yellow fever epidemic
|
1793
|
Philadelphia, United States
|
Yellow fever
|
5,000+
|
[104]
|
1800–1803 Spain yellow fever epidemic
|
1800–1803
|
Spain
|
Yellow fever
|
60,000+
|
[105]
|
1801 Ottoman Empire and Egypt bubonic plague epidemic
|
1801
|
Ottoman Empire, Egypt
|
Bubonic plague
|
Unknown
|
[106]
|
1802–1803 Saint-Domingue yellow fever epidemic
|
1802–1803
|
Saint-Domingue
|
Yellow fever
|
29,000–55,000
|
[107]
|
1812 Russia Typhus epidemic
|
1812
|
Russia
|
Typhus
|
300,000
|
[32]
|
1812–19 Ottoman plague epidemic (part of the Second plague pandemic)
|
1812–1819
|
Ottoman Empire
|
Bubonic plague
|
300,000+
|
[108]
|
1813–14 Malta plague epidemic (part of the Second plague pandemic)
|
1813–1814
|
Malta
|
Bubonic plague
|
4,500
|
[109]
|
Caragea's plague (part of the Second plague pandemic)
|
1813
|
Romania
|
Bubonic plague
|
60,000
|
[110]
|
1817–1819 Ireland typhus epidemic
|
1817–1819
|
Ireland
|
Typhus
|
65,000
|
[111]
|
First cholera pandemic
|
1817–1824
|
Asia, Europe
|
Cholera
|
100,000+
|
[112]
|
1820 Savannah yellow fever epidemic
|
1820
|
Savannah, Georgia, United States
|
Yellow fever
|
700
|
[113]
|
1821 Barcelona yellow fever epidemic
|
1821
|
Barcelona, Spain
|
Yellow fever
|
5,000–20,000
|
[114][115]
|
Second cholera pandemic
|
1826–1837
|
Asia, Europe, North America
|
Cholera
|
100,000+
|
[116]
|
1828–1829 New South Wales smallpox epidemic
|
1828–1829
|
New South Wales, Australia
|
Smallpox
|
19,000
|
[117][118]
|
Groningen epidemic
|
1829
|
Netherlands
|
Malaria
|
2,800
|
[119]
|
1829–1833 Pacific Northwest malaria epidemic
|
1829–1833
|
Pacific Northwest, United States
|
Malaria, possibly other diseases too
|
150,000
|
[120][121]
|
1829–1835 Iran plague outbreak
|
1829–1835
|
Iran
|
Bubonic plague
|
Unknown
|
[122]
|
1834–1836 Egypt plague epidemic
|
1834–1836
|
Egypt
|
Bubonic plague
|
Unknown
|
[123][124]
|
1837 Great Plains smallpox epidemic
|
1837–1838
|
Great Plains, United States and Canada
|
Smallpox
|
17,000+
|
[125]
|
1841 Southern United States yellow fever epidemic
|
1841
|
Southern United States (especially Louisiana and Florida)
|
Yellow fever
|
3,498
|
[126]
|
1847 North American typhus epidemic
|
1847–1848
|
Canada
|
Typhus
|
20,000+
|
[127]
|
1847 Southern United States yellow fever epidemic
|
1847
|
Southern United States (especially New Orleans)
|
Yellow fever
|
3,400
|
[128]
|
1847–1848 influenza epidemic
|
1847–1848
|
Worldwide
|
Influenza
|
Unknown
|
[129]
|
1848–1849 Hawaii epidemic of infections
|
1848–1849
|
Hawaiian Kingdom
|
Measles, whooping cough, dysentery and influenza
|
10,000
|
[130]
|
1853 New Orleans yellow fever epidemic
|
1853
|
New Orleans, United States
|
Yellow fever
|
7,970
|
[114]
|
Third cholera pandemic
|
1846–1860
|
Worldwide
|
Cholera
|
1 million+
|
[131]
|
1853 Ottoman Empire plague epidemic
|
1853
|
Ottoman Empire
|
Bubonic plague
|
Unknown
|
[132]
|
1853 Copenhagen cholera outbreak
|
1853
|
Copenhagen, Denmark
|
Cholera
|
4,737
|
[133]
|
1854 Broad Street cholera outbreak
|
1854
|
London, England
|
Cholera
|
616
|
[134]
|
1855 Norfolk yellow fever epidemic
|
1855
|
Norfolk and Portsmouth, England
|
Yellow fever
|
3,000 (2,000 in Norfolk, 1,000 in Portsmouth)
|
[135]
|
Third plague pandemic
|
1855–1960
|
Worldwide
|
Bubonic plague
|
12–15 million (India and China)
|
[136][137]
|
1857 Lisbon yellow fever epidemic
|
1857
|
Lisbon, Portugal
|
Yellow fever
|
6,000
|
[114]
|
1857 Victoria smallpox epidemic
|
1857
|
Victoria, Australia
|
Smallpox
|
Unknown
|
[138]
|
1857–1859 Europe and the Americas influenza epidemic
|
1857–1859
|
Europe, North America, South America
|
Influenza
|
Unknown
|
[139]
|
1862 Pacific Northwest smallpox epidemic
|
1862–1863
|
Pacific Northwest, Canada and United States
|
Smallpox
|
20,000+
|
[140][141][142]
|
1861–1865 United States typhoid fever epidemic
|
1861–1865
|
United States
|
Typhoid fever
|
80,000
|
[143]
|
Fourth cholera pandemic
|
1863–1875
|
Middle East
|
Cholera
|
600,000
|
[144]
|
1867 Sydney measles epidemic
|
1867
|
Sydney, Australia
|
Measles
|
748
|
[145]
|
1871 Buenos Aires yellow fever epidemic
|
1871
|
Buenos Aires, Argentina
|
Yellow fever
|
13,500–26,200
|
[146]
|
1870–1875 Europe smallpox epidemic
|
1870–1875
|
Europe
|
Smallpox
|
500,000
|
[147][148]
|
1875 Fiji measles outbreak
|
1875
|
Fiji
|
Measles
|
40,000
|
[149]
|
1875–1876 Australia scarlet fever epidemic
|
1875–1876
|
Australia
|
Scarlet fever
|
8,000
|
[145]
|
1876 Ottoman Empire plague epidemic
|
1876
|
Ottoman Empire
|
Bubonic plague
|
20,000
|
[150]
|
1878 New Orleans yellow fever epidemic
|
1878
|
New Orleans, United States
|
Yellow fever
|
4,046
|
[107]
|
1878 Mississippi Valley yellow fever epidemic
|
1878
|
Mississippi Valley, United States
|
Yellow fever
|
13,000
|
[107]
|
Fifth cholera pandemic
|
1881–1896
|
Asia, Africa, Europe, South America
|
Cholera
|
298,600
|
[151]
|
1885 Montreal smallpox epidemic
|
1885
|
Montreal, Canada
|
Smallpox
|
3,164
|
[152]
|
1889–1890 flu pandemic
|
1889–1890
|
Worldwide
|
Influenza or Human coronavirus OC43 / HCoV-OC43[153][154] (disputed)
|
1 million
|
[155]
|
1894 Hong Kong plague (part of the Third plague pandemic)
|
1894–1929
|
Hong Kong
|
Bubonic plague
|
20,000+
|
[156]
|
Bombay plague epidemic (part of the Third plague pandemic)
|
1896–1905
|
Bombay, India
|
Bubonic plague
|
20,788
|
[157]
|
1896–1906 Congo Basin African trypanosomiasis epidemic
|
1896–1906
|
Congo Basin
|
African trypanosomiasis
|
500,000
|
[158]
|
1899 Porto plague outbreak (part of the Third plague pandemic)
|
1899
|
Porto, Portugal
|
Bubonic plague
|
132
|
[159]
|
Sixth cholera pandemic
|
1899–1923
|
Europe, Asia, Africa
|
Cholera
|
800,000+
|
[160]
|
San Francisco plague of 1900–1904 (part of the Third plague pandemic)
|
1900–1904
|
San Francisco, United States
|
Bubonic plague
|
119
|
[161]
|
1900 Sydney bubonic plague epidemic (part of the Third plague pandemic)
|
1900
|
Australia
|
Bubonic plague
|
103
|
[162]
|
1900–1920 Uganda African trypanosomiasis epidemic
|
1900–1920
|
Uganda
|
African trypanosomiasis
|
200,000–300,000
|
[158]
|
Papua New Guinea kuru epidemic
|
1901–2009
|
Papua New Guinea
|
Kuru
|
2,700–3,000+
|
[163][164]
|
1903 India plague epidemic (part of the Third plague pandemic)
|
1903
|
India
|
Bubonic plague
|
22
|
[165]
|
1903 Fremantle plague epidemic (part of the Third plague pandemic)
|
1903
|
Fremantle, Western Australia
|
Bubonic plague
|
4
|
[166]
|
1906 malaria outbreak in Ceylon
|
1906–1936
|
Ceylon
|
Malaria
|
80,000
|
[167]
|
Manchurian plague (part of the Third plague pandemic)
|
1910–1911
|
China
|
Pneumonic plague
|
60,000
|
[168]
|
1910 China plague (part of the Third plague pandemic)
|
1910–1912
|
China
|
Bubonic plague
|
40,000
|
[169]
|
1915 Encephalitis lethargica pandemic
|
1915–1926
|
Worldwide
|
Encephalitis lethargica
|
500,000
|
[170][171][172]
|
1916 United States polio epidemic
|
1916
|
United States
|
Poliomyelitis
|
7,130
|
[173]
|
1918 influenza pandemic ('Spanish flu')
|
1918–1920
|
Worldwide
|
Influenza A virus subtype H1N1
|
17–100 million
|
[174][175][176]
|
1918–1922 Russia typhus epidemic
|
1918–1922
|
Russia
|
Typhus
|
2–3 million
|
[177]
|
1924 Los Angeles pneumonic plague outbreak
|
1924
|
Los Angeles, United States
|
Pneumonic plague
|
30
|
[178]
|
1924–1925 Minnesota smallpox epidemic
|
1924–1925
|
Minnesota, United States
|
Smallpox
|
500
|
[179]
|
1927 Montreal typhoid fever epidemic
|
1927
|
Montreal, Canada
|
Typhoid fever
|
538
|
[180]
|
1929–1930 Psittacosis Pandemic
|
1929–1930
|
Worldwide
|
Psittacosis
|
100+
|
[181]
|
Croydon typhoid outbreak of 1937
|
1937
|
Croydon, United Kingdom
|
Typhoid fever
|
43
|
[182]
|
1937 Australia polio epidemic
|
1937
|
Australia
|
Poliomyelitis
|
Unknown
|
[183]
|
1940 Sudan yellow fever epidemic
|
1940
|
Sudan
|
Yellow fever
|
1,627
|
[184]
|
1942–1944 Egypt malaria epidemic
|
1942–1944
|
Egypt
|
Malaria
|
Unknown
|
[123][124]
|
1946 Egypt relapsing fever epidemic
|
1946
|
Egypt
|
Relapsing fever
|
Unknown
|
[123][124]
|
1947 Egypt cholera epidemic
|
1947
|
Egypt
|
Cholera
|
10,277
|
[123][124][185]
|
1948–1952 United States polio epidemic
|
1948–1952
|
United States
|
Poliomyelitis
|
9,000
|
[173]
|
1957–1958 influenza pandemic ('Asian flu')
|
1957–1958
|
Worldwide
|
Influenza A virus subtype H2N2
|
1–4 million
|
[174][186][187]
|
1960–1962 Ethiopia yellow fever epidemic
|
1960–1962
|
Ethiopia
|
Yellow fever
|
30,000
|
[188]
|
Seventh cholera pandemic
|
1961–1975
|
Worldwide
|
Cholera (El Tor strain)
|
Unknown
|
[189]
|
Hong Kong flu
|
1968–1970
|
Worldwide (mainly in Hong Kong)
|
Influenza A virus subtype H3N2
|
1–4 million
|
[174][186][187]
|
1971 Staphorst polio epidemic
|
1971
|
Staphorst, Netherlands
|
Poliomyelitis
|
5
|
[190]
|
1972 Yugoslav smallpox outbreak
|
1972
|
Yugoslavia
|
Smallpox
|
35
|
[191]
|
London flu
|
1972–1973
|
United States
|
Influenza A virus subtype H3N2
|
1,027
|
[192]
|
1973 Italy Cholera El Tor epidemic
|
1973
|
Italy
|
Cholera (El Tor strain)
|
24
|
[193]
|
1974 smallpox epidemic of India
|
1974
|
India
|
Smallpox
|
15,000
|
[194]
|
1977 Russian flu
|
1977–1979
|
Worldwide
|
Influenza A virus subtype H1N1
|
700,000
|
[195][196]
|
Sverdlovsk anthrax leak
|
1979
|
Russia
|
Anthrax
|
105
|
[197]
|
HIV/AIDS pandemic
|
1981–present
|
Worldwide
|
HIV/AIDS
|
35 million+ (as of 2020)
|
[198]
|
1984 Western Sahara plague
|
1984
|
Western Sahara
|
Bubonic plague
|
64
|
[citation needed]
|
1986 Oju yellow fever epidemic
|
1986
|
Oju, Nigeria
|
Yellow fever
|
5,600+
|
[199]
|
1987 Mali yellow fever epidemic
|
1987
|
Mali
|
Yellow fever
|
145
|
[200]
|
1991 Bangladesh cholera epidemic
|
1991
|
Bangladesh
|
Cholera
|
8,410–9,432
|
[201]
|
1991 Latin America cholera epidemic
|
1991–1993
|
Peru, Chile, Bolivia, Ecuador, Colombia, Mexico, El Salvador, Guatemala
|
Cholera
|
8,000
|
[202][203]
|
1994 plague in India
|
1994
|
India
|
Bubonic plague and Pneumonic plague
|
56
|
[204]
|
United Kingdom BSE outbreak
|
1996–2001
|
United Kingdom
|
Variant Creutzfeldt–Jakob disease / vCJD
|
178
|
[205][206]
|
1996 West Africa meningitus epidemic
|
1996
|
West Africa
|
Meningitis
|
10,000
|
[207]
|
1998–99 Malaysia Nipah virus outbreak
|
1998–1999
|
Malaysia
|
Nipah virus infection
|
105
|
[208]
|
2000 Central America dengue epidemic
|
2000
|
Central America
|
Dengue fever
|
40+
|
[209]
|
2001 Nigeria cholera epidemic
|
2001
|
Nigeria
|
Cholera
|
400+
|
[210]
|
2001 South Africa cholera epidemic
|
2001
|
South Africa
|
Cholera
|
139
|
[211][212]
|
2002–04 SARS outbreak
|
2002–2004
|
Worldwide
|
Severe acute respiratory syndrome / SARS
|
774
|
[213]
|
2003 Algeria plague outbreak
|
2003
|
Algeria
|
Bubonic plague
|
1 (18 cases)
|
[214]
|
2003–2019 Asia and Egypt Avian influenza epidemic
|
2003–2019
|
Southeast Asia and Egypt
|
Influenza A virus subtype H5N1
|
455
|
[215]
|
2004 Afghanistan leishmaniasis epidemic
|
2004
|
Afghanistan
|
Leishmaniasis
|
0 (3,958 cases)
|
[216][217]
|
2004 Indonesia dengue epidemic
|
2004
|
Indonesia
|
Dengue fever
|
658
|
[218]
|
2004 Sudan ebola outbreak
|
2004
|
Sudan
|
Ebola
|
7
|
[219]
|
2005 dengue outbreak in Singapore
|
2005
|
Singapore
|
Dengue fever
|
27
|
[220]
|
2006 Luanda cholera epidemic
|
2006
|
Luanda, Angola
|
Cholera
|
1,200+
|
[221]
|
2006 Ituri Province plague epidemic
|
2006
|
Ituri Province, Democratic Republic of the Congo
|
Bubonic plague
|
61
|
[222][223]
|
2006 India malaria outbreak
|
2006
|
India
|
Malaria
|
17
|
[224]
|
2006 dengue outbreak in India
|
2006
|
India
|
Dengue fever
|
50+
|
[225]
|
2006 dengue outbreak in Pakistan
|
2006
|
Pakistan
|
Dengue fever
|
50+
|
[226]
|
2006 Philippines dengue epidemic
|
2006
|
Philippines
|
Dengue fever
|
1,000
|
[227]
|
2006–07 East Africa Rift Valley fever outbreak
|
2006–2007
|
East Africa
|
Rift Valley fever
|
394
|
[228]
|
Mweka ebola epidemic
|
2007
|
Democratic Republic of the Congo
|
Ebola
|
187
|
[229]
|
2007 Ethiopia cholera epidemic
|
2007
|
Ethiopia
|
Cholera
|
684
|
[230]
|
2007 Iraq cholera outbreak
|
2007
|
Iraq
|
Cholera
|
10
|
[231]
|
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic
|
2007
|
Puerto Rico, Dominican Republic, Mexico
|
Dengue fever
|
183
|
[232]
|
2007 Uganda ebola outbreak
|
2007
|
Uganda
|
Ebola
|
37
|
[219]
|
2007 Netherlands Q-fever epidemic
|
2007–2018
|
Netherlands
|
Q-fever
|
95
|
[233]
|
2008 Brazil dengue epidemic
|
2008
|
Brazil
|
Dengue fever
|
67
|
[234]
|
2008 Cambodia dengue epidemic
|
2008
|
Cambodia
|
Dengue fever
|
407
|
[235]
|
2008 Chad cholera epidemic
|
2008
|
Chad
|
Cholera
|
123
|
[236]
|
2008–2017 China hand, foot, and mouth disease epidemic
|
2008–2017
|
China
|
Hand, foot, and mouth disease
|
3,322+
|
[237]
|
2008 India cholera epidemic
|
2008
|
India
|
Cholera
|
115
|
[238]
|
2008 Madagascar plague outbreak
|
2008
|
Madagascar
|
Bubonic plague
|
18+
|
[239]
|
2008 Philippines dengue epidemic
|
2008
|
Philippines
|
Dengue fever
|
172
|
[240]
|
2008–09 Zimbabwean cholera outbreak
|
2008–2009
|
Zimbabwe
|
Cholera
|
4,293
|
[241]
|
2009 Bolivian dengue fever epidemic
|
2009
|
Bolivia
|
Dengue fever
|
18
|
[242]
|
2009 Gujarat hepatitis outbreak
|
2009
|
India
|
Hepatitis B
|
49
|
[243]
|
Queensland 2009 dengue outbreak
|
2009
|
Queensland, Australia
|
Dengue fever
|
1+ (503 cases)
|
[244]
|
Mumps outbreaks in the 2000s
|
2009
|
Worldwide
|
Mumps
|
Unknown
|
[citation needed]
|
2009–10 West African meningitis outbreak
|
2009–2010
|
West Africa
|
Meningitis
|
1,100
|
[245]
|
2009 swine flu pandemic
|
2009–2010
|
Worldwide
|
Influenza A virus subtype H1N1
|
Lab confirmed deaths: 18,449 (reported to the WHO)
Estimated death toll: 284,000 (possible range 151,700-575,400)
|
[246][247]
|
2010s Haiti cholera outbreak
|
2010–2019
|
Haiti
|
Cholera (strain serogroup O1, serotype Ogawa)
|
10,075
|
[248]
|
2010–2014 Democratic Republic of the Congo measles outbreak
|
2010–2014
|
Democratic Republic of the Congo
|
Measles
|
4,500+
|
[249][250]
|
2011 Vietnam hand, foot and mouth disease epidemic
|
2011
|
Vietnam
|
Hand, foot and mouth disease
|
170
|
[251][252]
|
2011 dengue outbreak in Pakistan
|
2011
|
Pakistan
|
Dengue fever
|
350+
|
[253]
|
2012 yellow fever outbreak in Darfur, Sudan
|
2012
|
Darfur, Sudan
|
Yellow fever
|
171
|
[254]
|
2012 Middle East respiratory syndrome coronavirus outbreak
|
2012–present
|
Worldwide
|
Middle East respiratory syndrome / MERS-CoV
|
935 (as of 4 July 2020[update])
|
[255]
|
2013 dengue outbreak in Singapore
|
2013
|
Singapore
|
Dengue fever
|
8
|
[256]
|
2013 Vietnam measles outbreak
|
2013–2014
|
Vietnam
|
Measles
|
142
|
[257]
|
Western African Ebola virus epidemic
|
2013–2016
|
Worldwide, primarily concentrated in Guinea, Liberia, Sierra Leone
|
Ebola
|
11,323+
|
[258][259][260]
|
2013–14 chikungunya outbreak
|
2013–2015
|
Americas
|
Chikungunya
|
183
|
[261]
|
2013–19 Avian influenza epidemic
|
2013–2019
|
China
|
Influenza A virus subtype H7N9
|
616
|
[262]
|
2014 Madagascar plague outbreak
|
2014–2017
|
Madagascar
|
Bubonic plague
|
292
|
[263]
|
2014 Odisha jaundice outbreak
|
2014–2015
|
India
|
Primarily Hepatitis E, but also Hepatitis A
|
36
|
[264]
|
2015 Indian swine flu outbreak
|
2015
|
India
|
Influenza A virus subtype H1N1
|
2,035
|
[265][266][267]
|
2015–16 Zika virus epidemic
|
2015–2016
|
Worldwide
|
Zika virus
|
53
|
[268]
|
2016 Angola and DR Congo yellow fever outbreak
|
2016
|
Angola and DR Congo
|
Yellow fever
|
498 (377 in Angola, 121 in Congo)
|
[269]
|
2016–20 Yemen cholera outbreak
|
2016–present
|
Yemen
|
Cholera
|
3,886 (as of 30 November 2019[update])
|
[270]
|
2017 dengue outbreak in Peshawar
|
2017
|
Peshawar, Pakistan
|
Dengue fever
|
69
|
[271]
|
2017 Gorakhpur Japanese encephalitis outbreak
|
2017
|
India
|
Japanese encephalitis
|
1,317
|
[272]
|
2017 dengue outbreak in Sri Lanka
|
2017
|
Sri Lanka
|
Dengue fever
|
440
|
[273]
|
2017–18 United States flu season
|
2017–2018
|
United States
|
Seasonal influenza
|
61,000 (46,000–95,000)[274]
|
[275][276][277]
|
2018 Nipah virus outbreak in Kerala
|
2018
|
India
|
Nipah virus infection
|
17
|
[278]
|
Kivu Ebola epidemic
|
2018–2020
|
Democratic Republic of the Congo and Uganda
|
Ebola
|
2,280
|
[279][280][281]
|
2018 NDM-CRE outbreak in Italy
|
2018–present
|
Italy
|
New Delhi metallo-beta-lactamase-producing Carbapenem-resistant enterobacteriaceae
|
31 (as of September 2019)
|
[282]
|
2019 measles outbreak in the Democratic Republic of the Congo
|
2019–2020
|
Democratic Republic of the Congo
|
Measles
|
7,018+
|
[283]
|
2019–2020 New Zealand measles outbreak
|
2019–present
|
New Zealand
|
Measles
|
2
|
[284]
|
2019 Philippines measles outbreak
|
2019
|
Philippines
|
Measles
|
415
|
[285]
|
2019 Kuala Koh measles outbreak
|
2019
|
Kuala Koh, Malaysia
|
Measles
|
15
|
[286]
|
2019 Samoa measles outbreak
|
2019–present
|
Samoa
|
Measles
|
83
|
[287]
|
2019–20 dengue fever epidemic
|
2019–present
|
Asia-Pacific, Latin America
|
Dengue fever
|
3,930
|
[288]
|
COVID-19 pandemic
|
2019–present
|
Worldwide
|
Coronavirus disease 2019 / COVID-19
|
2.5 million+ (as of February 2021)
|
[289]
|
2019 Nigeria lassa fever epidemic
|
2019–present
|
Nigeria
|
Lassa fever
|
246 (as of January 2021)
|
[290]
|
2020 Democratic Republic of the Congo Ebola outbreak
|
2020
|
Democratic Republic of the Congo
|
Ebola
|
55
|
[291]
|
2020 novel bunyavirus outbreak
|
2020–present
|
China
|
Severe fever with thrombocytopenia syndrome
|
7 (as of 5 August 2020)
|
[292]
|
2020 Nigeria yellow fever epidemic
|
2020–present
|
Nigeria
|
Yellow Fever
|
296 (as of 31 December 2020)
|
[293]
|