The Best American Science Writing is a yearly anthology of popular science articles published in the United States, which commenced publication in 2000. The books are published by Ecco Press (HarperCollins). As of 2013 the series editor is Jesse Cohen. Cohen was preceded as series editor by Alan Lightman. The series is unrelated to the Best American Series published by Houghton Mifflin Harcourt.
In 2010, HarperCollins also published The Best of the Best American Science Writing. The series' first ten guest editors selected their favorite essays to be re-published in this collection.